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ATROPISOMERISM FOR ENHANCED KINASE INHIBITOR SELECTIVITY
ATROPISOMERISM FOR ENHANCED KINASE INHIBITOR SELECTIVITY
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机译:星形胶质增强激酶抑制剂的选择性
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摘要
The invention provides a series of conformationally stable and selective kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly interconverting parent compounds. The compounds herein are atropisomers having increased kinase selectivity, and are for use in treating conditions that benefit from selective kinase inhibition.
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