METHOD FOR PREPARING COMPOSITION CONTAINING FACTOR 8 CAPABLE OF CONTROLLING CONTENT OF VON WILLEBRAND FACTOR (VWF) AND VON WILLEBRAND FACTOR

摘要

The present invention relates to a method for preparing a composition containing factor 8 (FVIII) capable of controlling the content of von Willebrand factor (vWF) and von Willebrand factor (vWF) and, more specifically, to a method for preparing a composition containing factor 8 (FVIII) capable of controlling the content of von Willebrand factor (vWF) and von Willebrand factor (vWF) by separately purifying factor 8 (FVIII) and von Willebrand factor (vWF) from plasma in a single process and mixing factor 8 (FVIII) and von Willebrand factor (vWF) at a proper ratio. According to the present invention, a composition containing factor 8 (FVIII), which variously changes the content of von Willebrand factor (vWF), and von Willebrand factor (vWF) can be produced/purified without increasing the amount of impurities other than von Willebrand factor (vWF), compared with a single purified product of factor 8 (FVIII), without significantly increasing the processing time (within 3 hours) compared with a single purification process of factor 8 (FVIII), and without changing the yield of factor 8 (FVIII).