首页> 外国专利> NEUTRALISING ANTIBODIES TO THE MAJOR EXOTOXIN TCDA OF CLOSTRIDIUM DIFFICILE

NEUTRALISING ANTIBODIES TO THE MAJOR EXOTOXIN TCDA OF CLOSTRIDIUM DIFFICILE

机译：艰难梭菌主要外毒素TCDA的中和抗体

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摘要

This present invention describes the derivation and selection of antibodies capable of neutralising the major exotox-in; TcdA of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of in-dividual Mabs and mixtures thereof.

机译：本发明描述了能够中和主要外毒素的抗体的衍生和选择。艰难梭菌的TcdA。本发明还描述了个体单克隆抗体及其混合物的新型中和作用和抗原结合特性。

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公开/公告号EP3617227A2

专利类型
公开/公告日2020-03-04

原文格式PDF
申请/专利权人 UCB BIOPHARMA SRL;
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申请/专利号EP20190160911
发明设计人 HUMPHREYS DAVID PAUL;LIGHTWOOD DANIEL JOHN;TYSON KERRY LOUISE;KNIGHT DAVID EDWARD ORMONDE;HERVÉ KARINE JEANNINE MADELEINE;COMPSON JOANNE ELIZABETH;PAGE MATTHEW JON TIMOTHY;PAYNE ANDREW CHARLES;FISHER NICOLA LOUISE;MACKENZIE BRENDON;COX MATTHEW;
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申请日2012-09-10
分类号C07K16/12;A61K39/40;A61P31/04;
国家 EP
入库时间 2022-08-21 11:38:02

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2. Research Advances of Exotoxin Gene and Related Vaccines of Clostridium perfringens [J] . Sun Yu, Wang Xiaoying, Dong Hao, 动物与饲料科学：英文版 . 2017,第002期

3. A novel multivalent, single-domain antibody targeting TcdA and TcdB prevents fulminant clostridium difficile infection in mice [J] . YangZ., SchmidtD., LiuW., The Journal of Infectious Diseases . 2014,第6期

4. A Mixture of Functionally Oligoclonal Humanized Monoclonal Antibodies That Neutralize Clostridium difficile TcdA and TcdB with High Levels of In Vitro Potency Shows In Vivo Protection in a Hamster Infection Model [J] . Nicola L. Davies, Joanne E. Compson, Brendon MacKenzie, Clinical and vaccine immunology: CVI . 2013,第3期

5. Antibody against TcdB, but not TcdA, prevents development of gastrointestinal and systemic Clostridium difficile disease. [J] . Jennifer Steele, Jean Mukherjee, Nicola Parry, The Journal of Infectious Diseases . 2013,第2期

6. Evaluation of the Ability of Di-tri-octahedral Smectite to Adhere to Clostridium difficile Toxins and Clostridium perfringens Enterotoxin In Vitro [C] . J. S. Weese, N. M. Cote, R. V. G. deGannes Annual Convention of the American Association of Equine Practitioners . 2002

7. Large-scale production in Escherichia coli TG1 and purification of llama single domain antibody ToxA5.1 against Clostridium difficile toxin A. [D] . Parisien, Albert. 2013

8. Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface [O] . Heather K. Kroh, Ramyavardhanee Chandrasekaran, Kim Rosenthal, 2017

9. Novel Clostridium difficile Anti-Toxin (TcdA and TcdB) Humanized Monoclonal Antibodies Demonstrate In Vitro Neutralization across a Broad Spectrum of Clinical Strains and In Vivo Potency in a Hamster Spore Challenge Model. [O] . Hongyu Qiu, Robyn Cassan, Darrell Johnstone, 2016

10. Hybridoma Cell Lines amd Monoclonal Antibodies to Clostridium difficile Toxins A and B. [R] . Rothman, S., Gentry, M. K. 1986

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