Research Advances of Exotoxin Gene and Related Vaccines of Clostridium perfringens

摘要

Clostridium perfringens,also called clostridium westergren,mainly causes diseases in ruminants,such as gas gangrene,enterotoxaemia,hemorrhagic enteritis of cattle and sheep. The bacteria are divided into five subtypes including A,B,C,D and E subtype,which can secrete more than 10 kinds of exotoxin,such as α,β,ε,ι,γ,η,θ,κ,λ,μ,ν and so on. In these toxins,α,β,ε and ι play a key pathogenic role. At present,the disease is prevented mainly by univalent vaccine,combined vaccine and multivalent inactivated vaccine. And the genetic engineering subunit vaccine and nucleic acid vaccine has wide development prospects. In order to provide some reference for comprehensive prevention and deep research of C. perfringens,the etiological characteristics of C. perfringens,pathogenic mechanism of exotoxin and research progress of related vaccines were reviewed,and the genetic engineering subunit vaccine and nucleic acid vaccine development prospects were also discussed in this paper.