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COMBINATION OF TWO ANTIVIRAL AGENTS FOR TREATING HEPATITIS C

机译:两种抗病毒药物联合治疗丙型肝炎

摘要

To provide novel methods for treating hepatitis C virus (HCV) infection, the methods avoiding side effects associated with a combination of interferon, such as peginterferon alpha, with ribavirin used in the prior art.SOLUTION: A method for treatment for the HCV comprises administering at least two direct acting antiviral agents (DAAs) to an HCV patient. Neither interferon nor ribavirin are administered to the patient during the treatment, and the treatment lasts for 8, 9, 10, 11 or 12 weeks. The at least two DAAs comprise a specific HCV protease inhibitor or a pharmaceutically acceptable salt thereof, and a specific NS5A inhibitor or a pharmaceutically acceptable salt thereof.SELECTED DRAWING: Figure 1
机译:为了提供治疗丙型肝炎病毒(HCV)感染的新方法,该方法避免了与干扰素(例如聚乙二醇干扰素α)和现有技术中使用的利巴韦林联合使用所引起的副作用。解决方案:治疗HCV的方法包括给药至少有两种直接作用于HCV患者的抗病毒药(DAA)。在治疗期间既不给患者施用干扰素,也不给予利巴韦林治疗,治疗持续8、9、10、11或12周。所述至少两种DAA包含特定的HCV蛋白酶抑制剂或其药学上可接受的盐,以及特定的NS5A抑制剂或其药学上可接受的盐。

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