GENE DETECTION ASSAY FOR IMPROVING LIKELIHOOD OF EFFECTIVE RESPONSE TO ERBB ANTAGONIST CANCER THERAPY

摘要

PROBLEM TO BE SOLVED: To provide a method for more effective treatment of patients susceptible to or diagnosed with tumors overexpressing ErbB, e.g., determined by a gene amplification assay, with an ErbB antagonist.;SOLUTION: A method for increasing the likelihood of effectiveness of an ErbB antagonist cancer treatment comprises administering a cancer-treating dose of the ErbB antagonist to a subject, where an erbB gene in tumor cells in a tissue sample from the subject has been found to be amplified. The ErbB antagonist includes an anti-HER2 antibody. The method further comprises additionally administering a chemotherapeutic agent such as a taxoid.;SELECTED DRAWING: None;COPYRIGHT: (C)2020,JPO&INPIT