TREATMENT OF C1013G/CXCR4-ASSOCIATED WALDENSTROM'S MACROGLOBULINEMIA WITH ANTI-CXCR4 ANTIBODY

摘要

PROBLEM TO BE SOLVED: To provide a method for treating a subject afflicted with C1013G/CXCR4-associated Waldenstrom's macroglobulinemia (WM).;SOLUTION: The method comprises administering to the subject a therapeutically effective amount of an antibody or an antigen-binding portion thereof that specifically binds to a C-X-C chemokine receptor type 4 (CXCR4) receptor expressed on the surface of a Waldenstrom's macroglobulinemia cell. The disclosure also provides a therapeutic regimen for treating a patient afflicted with C1013G/CXCR4-associated WM.;SELECTED DRAWING: None;COPYRIGHT: (C)2020,JPO&INPIT