A novel 2,3,5-substituted thiophene compound that is a protein kinase inhibitor

摘要

PROBLEM TO BE SOLVED: To provide a new compound having an inhibitory activity against a drug resistance point mutation of FLT3 as a target therapeutic agent for acute myeloid leukemia (AML), and an anticancer agent containing the compound as an active ingredient. SOLUTION: The compound is composed of a 2,3,5-substituted thiophene compound represented by the following chemical formula 1a, a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof and a stereoisomer and a geometric isomer thereof. Compounds selected from the group. [Z is O; A is phenyl group, etc .; R1 is halo, etc .; R2 is H; n is an integer of 1-3]