Biomarkers and diagnostic methods for Alzheimer's disease and other neurodegenerative disorders

摘要

PROBLEM TO BE SOLVED: To provide biomarkers for Alzheimer's disease and other neurodegenerative disorders, as well as diagnostic methods and prognosis determination methods. Assaying the level of one or more biomarkers in a biological sample from a subject, then diagnosing or prognosing a neurodegenerative disorder in the subject based on the level of the biomarker, risk of neurodegenerative disorder. At least one or more biomarkers include tau, phosphorylated tau, Aβ1-42, including identifying a subject with or prescribing a treatment regimen in a subject with a neurodegenerative disorder or predicting the benefit of treatment. , TDP-43, α-synuclein, SOD-1, FUS, FKBP51, IRS-1, phosphorylated IRS-1, CTSD, LAMP1, UBP, HSP70, NSE, NFL, CD9, CD63, CD81 and CD171. The method of choice. [Selection diagram] None