Dual regulators of farnesoid X receptor and soluble epoxide hydrolase

摘要

The present invention relates to novel dual regulators of farnesoid X receptor (FXR) and soluble epoxide hydrolase (sEH). The modulators of the present invention were designed to provide compounds with dual activity as agonists of FXR and inhibitors of sEH. The invention also provides a method for treating a subject suffering from a disease associated with FXR and sEH, such as a metabolic disorder, specifically non-alcoholic fatty liver or non-alcoholic steatohepatitis (NASH). To do.