首页> 外国专利> COMPOSITION CONTAINING FOXK1 INHIBITOR AND METHOD FOR SCREENING CANDIDATE SUBSTANCE HAVING FOXK1 INHIBITORY ACTION

COMPOSITION CONTAINING FOXK1 INHIBITOR AND METHOD FOR SCREENING CANDIDATE SUBSTANCE HAVING FOXK1 INHIBITORY ACTION

机译:包含foxk1抑制剂的组合物和具有foxk1抑制作用的候选扁桃酸酯物质的筛选方法

摘要

To provide more potent FOXK1 inhibitors, and also to provide screening of candidate substances having FOXK1 inhibitory activity.SOLUTION: The compounds described in the specification are provided. Provided is a method for screening candidate substance having FOXK1 inhibitory action, comprising: obtaining the measured value that reflects the expression of CCL2, and/or FBXO32 in a cell contacted with the test substance; and if the measured value is lower than the measured value that reflects the expression of CCL2 and/or FBXO32 when the test substance is not contacted, determining that the test substance is a candidate substance having FOXK1 inhibitory action.SELECTED DRAWING: None
机译:为了提供更有效的FOXK1抑制剂,并提供具有FOXK1抑制活性的候选物质的筛选。解决方案:提供了说明书中所述的化合物。提供一种筛选具有FOXK1抑制作用的候选物质的方法,该方法包括:获得反映与被测物质接触的细胞中CCL2和/或FBXO32的表达的测量值;如果测量值低于反映未接触测试物质时CCL2和/或FBXO32表达的测量值,则确定该测试物质是具有FOXK1抑制作用的候选物质。

著录项

  • 公开/公告号JP2020055759A

    专利类型

  • 公开/公告日2020-04-09

    原文格式PDF

  • 申请/专利权人 KYUSHU UNIV;

    申请/专利号JP20180185599

  • 发明设计人 NAKAYAMA KEIICHI;

    申请日2018-09-28

  • 分类号A61K45;G01N33/50;G01N33/15;A61P35;A61P43;A61K31/472;

  • 国家 JP

  • 入库时间 2022-08-21 11:36:16

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