Asymmetric heterodimer FC-SCFV fusion anti-GLOBOH and anti-CD3 bispecific antibody and its use in cancer therapy

摘要

The bispecific anti-Globo H antibody comprises an anti-Globo H antibody that specifically binds to Globo H and a T cell targeting domain fused to the CH3 domain of the heavy chain of the anti-Globo H antibody. Specificly binds to an antigen on a T cell, and the anti-Globo H antibody contains a mutation at the effector binding site such that the bispecific anti-Globo H antibody has reduced effector function. The T cell targeting domain is ScFv or Fab from an anti-CD3 antibody.