Psychiatric disease model animal and production method thereof

摘要

The present invention relates to a method for producing a non-human model animal for a psychiatric disease, which comprises the step of (a) losing the function of all or a part of the caryopherin α (KPNA) 1 gene or a homolog thereof in the non-human animal. On the method. The present invention also relates to a non-human model animal of a psychiatric disease produced by the method or a progeny thereof, and a tissue or a cell isolated from the animal. The present invention further relates to a method for screening a preventive or therapeutic agent for a mental disease, a method for evaluating the efficacy and / or toxicity of a test substance for a mental disease, and a method for screening a biomarker for a mental disease, using the animal.