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Removal of unbound drug after antibody-drug conjugate binding
Removal of unbound drug after antibody-drug conjugate binding
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机译:抗体-药物偶联物结合后未结合药物的去除
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摘要
An ultrafiltration and purification unit (1) of a product stream (3) containing a biopolymer product and a substance to be separated from the product stream, comprising at least one capillary ultrafiltration module (2). The ultrafiltration and purification unit (1) is: -At least one pump (4) transports the product stream into the capillaries of at least one capillary ultrafiltration module. -At least one positive displacement pump (5) transports the product stream from the capillaries. -At least one additional pump (6) flushes the cleaning solution (9) to the outside of the capillaries. -The unit does not have the means to circulate the product stream and cleaning fluid into the ultrafiltration module. An ultrafiltration and purification unit (1) comprising at least one guard filter (8) through which all fluid exiting the at least one capillary ultrafiltration module passes in the direction of the product flow. Disclosure in the specification.
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