Antimicrobial peptides and mixtures thereof that exhibit antimicrobial activity against Gram-negative pathogens

摘要

The present invention relates to the fields of medicine and microbiology, specifically means and methods for treating infections caused by Gram-negative pathogens (particularly drug resistant or prone to develop). (I) Intimal action compounds having membrane permeation activity and / or Lipid II binding activity, and (ii) RRLFRRILRWL-NH ₂ (GNP-6), GNNRPVYIPQPRPPHPRL (GNP-1), RIWVIWRR-NH ₂ (GNP-5). ), GIGKHVGKALKGLKGLLKGLGEC (GNP-7), and X ₁ X ₂ IVQRIKKWLX _3- NH ₂ (X ₁ is absent or K, X ₂ is R, K, or A, X ₃ is absent or R A mixture of one or more antimicrobial peptides selected from the group consisting of (is) is provided. [Selection diagram] None