METHODS OF DIAGNOSIS, PROGNOSIS AND TREATMENT OF BREAST CANCER METASTASIS

摘要

To provide methods for diagnosis, prognosis and treatment of breast cancer metastasis.SOLUTION: The invention relates to a method for diagnosis or prognosis of metastasis in breast cancer, comprising a step of determining whether the c-MAF gene is amplified or not in a primary tumor sample. The invention also relates to a method of diagnosis or prognosis of metastasis in ER-breast cancer, as well as to a method for determining the tendency to develop bone metastasis with respect to metastasis in other organs, which methods comprise determining the c-MAF gene expression level. Finally, the invention relates to the use of a c-MAF inhibitor as a therapeutic target for treating the ER-breast cancer metastasis.SELECTED DRAWING: None