IFN-γ-induced regulatory T cell converting anti-cancer (IRTCA) antibody and use thereof

摘要

Provided are IFN-γ-induced regulatory T cell converting anti-cancer (IRTCA) antibodies and antigen-binding fragments thereof that bind to an activation-inducible TNFR (AITR) polypeptide. Various in vitro and in vivo methods and compositions related to the IRTCA antibodies described herein are also provided. The methods include altering cytokine secretion from T cells in vivo or in vitro, e.g., using an IRTCA antibody or fragment thereof, and preventing and / or treating cancer using the IRTCA antibody or fragment thereof. Actions are included.