SPIROQUINOXALINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH

摘要

To provide compounds which are inhibitors of non-apoptotic regulated cell death, and pharmaceutical compositions containing such compounds.SOLUTION: There are provided spiroquinoxaline derivatives for use in the treatment method of a condition, disorder or disease that is characterized by activation of (1) one or more components of the necrosome; (2) death domain receptors; and/or (3) Toll-like receptors; and/or (4) players in ferroptotic/ferroptosis signalling, or where activation of any one of (1) to (3) and/or (4) is likely to play or plays a substantial role.SELECTED DRAWING: None