首页> 外国专利> Heterodimer bispecific antibody having anti-PD-1 / anti-HER2 natural antibody structural form and method for producing the same

Heterodimer bispecific antibody having anti-PD-1 / anti-HER2 natural antibody structural form and method for producing the same

机译:具有抗PD-1 /抗HER2天然抗体结构形式的异二聚体双特异性抗体及其制备方法

摘要

The present invention relates to an anti-PD-1 / anti-HER2 natural antibody structural form heterodimeric bispecific antibody and a method for producing the same. Specifically, a highly stable heterodimeric anti-PD-1 / anti-HER2 bispecific antibody, which has properties of natural IgG and has no mismatch between heavy and light chains, and A method for producing the same is provided, and the bispecific antibody can bind to two target molecules at the same time, and exhibits a further excellent effect in treating a complex disease.
机译:本发明涉及抗PD-1 /抗HER2天然抗体结构形式的异二聚双特异性抗体及其制备方法。具体而言,提供了具有天然IgG的性质且在重链和轻链之间没有错配的高度稳定的异源二聚抗PD-1 /抗HER2双特异性抗体,提供了其制备方法,该双特异性抗体可以结合同时作用于两个靶分子,在治疗复杂疾病方面显示出进一步优异的效果。

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