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TENELIGLIPTIN-CONTAINING PHARMACEUTICAL COMPOSITIONS, METHODS FOR MAKING THE SAME, TENELIGLIPTIN-CONTAINING TABLETS AND PRODUCTION METHODS THEREOF
TENELIGLIPTIN-CONTAINING PHARMACEUTICAL COMPOSITIONS, METHODS FOR MAKING THE SAME, TENELIGLIPTIN-CONTAINING TABLETS AND PRODUCTION METHODS THEREOF
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机译:含替格列汀的药物组合物,其制备方法,含替格列汀的片剂及其生产方法
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To provide pharmaceutical compositions containing teneligliptin hydrobromide maintaining an amorphous state, teneligliptin-containing tablets of which analog increase is suppressed, or teneligliptin-containing tablets of which decrease in dissolution rate during storage period is suppressed.SOLUTION: Amorphous teneligliptin hydrobromide is in coexistence with an amorphousness-maintaining polymer. The amorphousness-maintaining polymer may be one or more selected from the group consisting hydroxypropyl cellulose of 16.0% or more substitution degree, polyvinylpyrrolidone, hipromellose, hipromellose acetate succinate, methacrylate copolymer LC and aminoalkyl methacrylate copolymer E.SELECTED DRAWING: Figure 1
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