SPINAL SUBPIAL GENE DELIVERY SYSTEMS

摘要

PROBLEM TO BE SOLVED: To provide a method for delivering a nucleic acid molecule to the subpial space of a mammal to achieve spinal parenchymal infection thereof, and a system for spinal subpial gene delivery.;SOLUTION: Provided herein is a method for delivering a nucleic acid molecule to the subpial space of a subject comprising the steps of: exposing a spinal segment of the vertebra of the subject; creating a pial opening within the spinal segment by puncturing the pia with an L-shaped stainless steel tube; advancing a catheter through the pial opening and into subpial space; and delivering the nucleic acid molecule to the subpial space of the subject, where the nucleic acid molecule is a vector or antisense oligonucleotide (ASO), and a system used in the method is also provided.;SELECTED DRAWING: None;COPYRIGHT: (C)2020,JPO&INPIT