Methods of treating diseases that contribute to maladaptive stress responses

摘要

The present invention relates to a method for reversing maladaptations involving corticotropin releasing factor receptor subtype 2 (CRFR2). In functional somatic syndrome (FSS), a group of diseases with overlapping symptoms, including generalized intolerance disease (also known as SEID, chronic fatigue syndrome or myalgic encephalomyelitis), and several others It is hypothesized that this receptor is up-regulated and relocated to neuronal membranes in major brain regions including the raphe nucleus, limbic system and cortex. This arrangement leads to a dysfunctional stress response. According to one embodiment of the present invention, a method for reversing CRFR2 maladaptation continually stimulates a receptor over a period of time resulting in persistent receptor endocytosis, resulting in measurable symptom improvement Including that.