System, method and computer readable medium for basal rate profile adaptation algorithm for closed loop artificial pancreas system

摘要

An insulin device configured to control insulin dose by adapting a basal rate profile. The insulin device includes a sensor configured to generate blood glucose measurement data and detect changes in the blood glucose measurement data over time, and a processor configured to receive the blood glucose measurement data and a basal rate profile and associated And a basal rate profile including a basal rate setpoint corresponding to an insulin delivery criterion for a nominal blood glucose level, the basal rate profile stored in the computer memory device. The insulin device also includes an insulin dispensing valve controlled by the processor to administer insulin according to the received basal rate profile, the processor at least one of a hyperglycemic risk and a hypoglycemic risk from the blood glucose level data. It is configured to update the basal rate setpoint over a period of time based on both the assessment of the risk and the pattern of motion performed by the insulin device during the period of time to mitigate blood glucose risk. The insulin dispense valve is controlled by the processor to deliver insulin according to the updated basal rate setpoint. [Selection diagram] Figure 1