SYSTEM, METHOD, AND COMPUTER READABLE MEDIUM FOR A BASAL RATE PROFILE ADAPTATION ALGORITHM FOR CLOSED-LOOP ARTIFICIAL PANCREAS SYSTEMS

摘要

An insulin device configured to control an insulin dosage by adapting a basal rate profile. The insulin device includes a sensor configured to produce a blood glucose level measurement data, and detect changes of the blood glucose level measurement data over time; a processor and associated computer memory device configured to receive the blood glucose level measurement data and a basal rate profile, such that the basal rate profile includes a basal rate set point that corresponds to an insulin delivery reference for a nominal blood glucose, and the basal rate profile is stored in the computer memory device. The insulin device also includes an insulin dispensing valve controlled by the processor to administer insulin in accordance with the received basal rate profile, such that the processor is configured to update the basal rate set point over a time period based on both an assessment of at least one of a risk of hyperglycemia and a risk of hypoglycemia from historical blood glucose data, and patterns of actions taken by the insulin device to mitigate glycemic risk during the time period. The insulin dispensing valve is controlled by the processor to administer insulin in accordance with the updated basal rate set point.