Selective TNFR1 antagonist peptide SN10 and its use in inflammatory bowel disease

摘要

A snake venom of the Madaraumi snake having the amino acid sequence shown in SEQ ID NO: 2 and capable of achieving selective modification by covalent bond between the carboxyl group of mPEG2000 and the free amino group of the N-terminal aspartic acid of the peptide chain of Hydrostatin-SN10. Derivatives of selective TNFR1 antagonist peptide Hydrostatin-SN10 are provided. The selective TNFR1 antagonist peptides Hydrostatin-SN10 and PEG-SN10 are applicable for the treatment of inflammatory bowel disease. [Selection diagram] None