Use of an immune checkpoint modulator in combination with antigen-specific T cells in adoptive immunotherapy

摘要

As used herein, the administration of an inhibitory immune checkpoint inhibitor or a stimulatory immune checkpoint activator to a human patient and the T cell line derived from a subdominant HLA allele or a combination of HLA alleles Administering to a human patient a population of human cells comprising antigen-specific T cells. Methods for selecting such T cell lines for therapeutic administration to human patients in combination with the administration of an inhibitory immune checkpoint inhibitor or a stimulatory immune checkpoint activator and such T cell lines Also provided is a method of selecting a T cell donor from which to derive. Pharmaceutical compositions comprising an inhibitory immune checkpoint inhibitor or a stimulatory immune checkpoint activator, and antigen-specific T cells from a T cell line restricted by a subdominant HLA allele or a combination of HLA alleles. Also provided is a population of human cells comprising: