Multispecific binding proteins for the activation of natural killer cells and their therapeutic use for treating cancer

摘要

Multispecific binding proteins that bind to tumor-associated antigens, NKG2D receptor, and CD16, as well as pharmaceutical compositions and therapeutic methods useful for treating cancer are described. The multispecific binding protein binds to tumor-associated antigens in cancer cells and NKG2D receptor and CD16 receptor in natural killer cells to activate natural killer cells and associates with two or more NK-activating receptors And prevent binding of the natural ligand to NKG2D.