Compositions with enhanced potency and safety and use for topical application of antimicrobial synthetic cationic polypeptides

摘要

The antimicrobial pharmaceutical composition is formulated to allow topical in vivo application of a dose that provides a low risk of local tissue toxicity and / or a low risk of systemic / distant organ toxicity but provides antimicrobial efficacy. .. In various embodiments, the antimicrobial pharmaceutical composition comprises an antimicrobial synthetic cationic polypeptide dispersed in an aqueous carrier and formulated to achieve a desired degree of polymer self-assembly and / or composition viscosity.