Antibody against GD2-O-acetylated ganglioside having pro-apoptotic activity

摘要

The present invention concerns an antibody, or functional fragment thereof, which binds specifically to the O-acetylated-GD2 ganglioside, said antibody comprising a) a light chain comprising three light chain complementary regions (CDRs) having the following amino acid sequences: the light chain CDR1: QSLLKNNGNTFL (SEQ id n°1), the light chain CDR2: KVS, the light chain CDR3: SQSTHIPYT (SEQ id n°2); and a light chain framework sequence from an immunoglobulin light chain, wherein said framework sequence comprises the human kappa (º)CL domain; and b) a heavy chain comprising three heavy chain complementary regions (CDRs) having the following amino acid sequences: the heavy chain CDR1: EFTFTDYY (SEQ id n°3), the heavy chain CDR2: IRNRANGYTT (SEQ id n°4), the heavy chain CDR3: ARVSNWAFDY (SEQ id n°5), and a heavy chain framework sequence from an immunoglobulin heavy chain, wherein said framework sequence comprises the CH2 and CH3 domains from a human IgG1, and a CH1 domain from a human IgG1, which is mutated so as to restore the pairing between CH1 and light chain that is typical of other human IgG subclasses or substituted by a CH1 domain from such non-IgG1 subclasses as human IgG2, IgG3 or IgG4; and its use in therapy.