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Method for producing 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
Method for producing 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
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机译:1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸的生产方法
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摘要
The present invention discloses a method for producing 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA). The production method of the present invention comprises a step of subjecting a cyclen to an XCH2COOR alkylation reaction in water under the action of an acid binder, a step of precipitating a DOTA crude product by adjusting a pH value, and a step of recrystallization. And The production method of the present invention is suitable for large-scale industrial production of DOTA, and is purified by using an ion-exchange resin or means of low-temperature freezing throughout the process, and both the purity and yield of the product are high. Embedded image
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