THYMIDINE KINASE DIAGNOSTIC ASSAY FOR GENE THERAPY APPLICATIONS

摘要

PROBLEM TO BE SOLVED: To provide methods and compositions for identifying subjects or patients who can benefit from gene therapy treatment.;SOLUTION: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.;SELECTED DRAWING: Figure 1;COPYRIGHT: (C)2020,JPO&INPIT