BAG3 as a biochemical serum marker and tissue marker

摘要

The present disclosure concerns the field of diagnostic serum and tissue markers. Specifically the disclosure relates to anti-BAG3 antibodies for use as serum markers of a pathological state. Furthermore, the disclosure involves specific ELISA methods and kits, for detecting and evaluating, anti-BAG3 antibodies or BAG3/antibody complexes in a biological sample. The disclosure further relates to an immunohistochemistry kit to detect and evaluate intracellular BAG3, in specific physiopathological states (heart diseases, pancreatic cancer, bladder carcinoma). Furthermore the disclosure involves BAG3-specific antibodies, their modified derivatives, and peptides for modulation of macrophage activation.