PDX1 pancreatic endoderm cell in cell delivery device and method thereof

摘要

Disclosed are devices and methods for transplanting cells, such as pancreatic endoderm cells, into a host. The device can include a nonwoven on the outside of the cell exclusion membrane, and can perforate the nonwoven and / or cell exclusion membrane. Treatment of the host with an immunosuppressive reagent is required to suppress allograft rejection due to perforation of the cell delivery device and does not impair the maturity or function of the transplanted pancreatic endoderm cells.