Pharmaceutical composition for preventing and / or treating abnormal blood coagulation factor IX, comprising a multispecific antigen-binding molecule that substitutes for the function of blood coagulation factor VIII

摘要

The present inventors have examined the procoagulant effect of a multispecific antigen-binding molecule that substitutes for the function of FVIII, using blood and plasma from a patient with FIX abnormality. As a result, a multispecific antigen-binding molecule that substitutes for FVIII functions against bleeding in hemophilia A, acquired hemophilia A, von Willebrand disease, and hemophilia C due to FVIII dysfunction. Its procoagulant activity indicates that it can be used not only as a prophylactic and / or therapeutic method, but also as a preventive and / or therapeutic method for bleeding in FIX disorders. In addition, the effects of FIX preparations can be enhanced by using a combination of a multispecific antigen-binding molecule that substitutes for FVIII and a FIX preparation, indicating that it is promising as a combination therapy showing a stable hemostatic effect. .