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Crystalline form of dextral oxiracetam, preparation method therefor and use thereof

机译:右旋奥拉西坦的晶型,其制备方法及其用途

摘要

The present invention provides a crystalline form of dextral oxiracetam. The crystalline form has a diffraction peak when a diffraction angle, 2θ, is 17.12±0.2°, 18.88±0.2°, 19.24±0.2°, 21.18±0.2°, 24.88±0.2°. The crystalline form having oxiracetam can promote synthesis of phosphorylcholine and phosphoethanolamine, boosts cerebral metabolism, has a stimulating function on a specific central nervous pathway through a blood-brain barrier, improves the intelligence and memory, has an obvious effect on a memory dysfunction, and has special biologic activity in the field of sedation and the antiepileptic field. The method for preparing the crystalline form is simple and is suitable for industrial production.
机译:本发明提供了右旋奥拉西坦的结晶形式。当衍射角2θ为17.12±0.2°,18.88±0.2°,19.24±0.2°,21.18±0.2°,24.88±0.2°时,该结晶形式具有衍射峰。具有奥拉西坦的晶体形式可以促进磷酸胆碱和磷酸乙醇胺的合成,促进大脑代谢,通过血脑屏障对特定的中枢神经通路具有刺激作用,改善智力和记忆力,对记忆功能障碍有明显作用,并且在镇静和抗癫痫领域具有特殊的生物活性。制备晶体形式的方法简单,适合工业生产。

著录项

  • 公开/公告号US10696629B2

    专利类型

  • 公开/公告日2020-06-30

    原文格式PDF

  • 申请/专利权人 CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED;

    申请/专利号US201716344337

  • 发明设计人 LEI YE;

    申请日2017-07-07

  • 分类号C07D207/273;

  • 国家 US

  • 入库时间 2022-08-21 11:30:42

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