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Respiratory syncytial virus having cleavage-resistant G protein and related materials and methods
Respiratory syncytial virus having cleavage-resistant G protein and related materials and methods
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机译:具有抗切割G蛋白的呼吸道合胞病毒及其相关材料和方法
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摘要
Embodiments disclosed herein provide compositions, methods, and uses for respiratory syncytial viruses (RSV) and immunogenic compositions thereof. Certain embodiments provide RSV having cleavage-resistant mutated attachment (G) glycoproteins. In some embodiments, the cleavage-resistant G protein mutants increase production of live attenuated RSV in host cells. Also provided are methods for amplifying RSV in host cells, wherein the amplified RSV has full length G protein. In certain embodiments, the amplified RSV having full length G protein is formulated into immunogenic compositions, including vaccines. Other embodiments provide methods for inducing an effective immune response against RSV infection in a subject.
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