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Heterobifunctional linkers with polyethylene glycol segments and immune response modifier conjugates made therefrom
Heterobifunctional linkers with polyethylene glycol segments and immune response modifier conjugates made therefrom
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机译:具有聚乙二醇链段的异双功能接头和由其制得的免疫应答修饰物偶联物
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摘要
Conjugates of an immune response modifier, a linker, and an antigen are disclosed. The linker is represented by formula:; ;wherein A is CH or N, p is in a range from 1 to 50, R″ is a bond or -alkylene-O—, R′ is alkylene that is optionally interrupted or terminated with one or more amide or ether groups, and E is an amine- or thiol-reactive group. Pharmaceutical compositions containing the compound or the conjugate, methods of making a conjugate, and methods of use of the compounds or conjugates as immunomodulators for inducing cytokine biosynthesis in an animal and for vaccinating an animal are also disclosed. An antigen modified by the linker is also disclosed.
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