An isolation flange assembly including a body including a receptacle disposed therein, and a first seal assembly disposed in the receptacle of the body, wherein the first seal assembly is configured to sealingly engage an inner surface of the receptacle of the body and an outer surface of a tubular member extending into the receptacle of the body, wherein the first seal assembly includes an annular radially outer seal, and an annular radially inner seal in engagement with the outer seal.
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