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Stable nimodipine parenteral formulation

机译:稳定的尼莫地平肠胃外制剂

摘要

A nimodipine injection concentrate and diluted formulation comprises nimodipine (base or salt), an effective amount of a hydrophilic surfactant, and a pharmaceutically acceptable carrier for injection which is an aqueous solution, an organic solvent, an oil, or a cyclodextrin, such that the nimodipine is substantially contained in a concentrated injection solution, suspension, emulsion or complex as a micelle or a colloidal particle or an inclusion complex and the formulation is stable and clear. In certain embodiments, the hydrophilic surfactant is polysorbate 80.
机译:尼莫地平注射浓缩物和稀释制剂包含尼莫地平(碱或盐),有效量的亲水性表面活性剂和注射用药学上可接受的载体,其为水溶液,有机溶剂,油或环糊精,以使尼莫地平基本上以胶束或胶体颗粒或包合物的形式包含在浓缩注射溶液,悬浮液,乳剂或复合物中,并且制剂稳定透明。在某些实施方案中,亲水性表面活性剂是聚山梨酯80。

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