COMPOSITIONS AND METHODS FOR INHIBITION OF THE LNCRNA SAF TO DRIVE APOPTOTIC CELL DEATH IN HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTED HUMAN MACROPHAGES

摘要

Provided are compositions and methods for prophylaxis or therapy for human immunodeficiency virus (HIV) infection. The compositions and methods involve use of RNAi agents targeted to an anti-apoptotic long non-coding RNA (lncRNA) that is IncRNA SAF (FAS-AS1) or HOXA-AS2. The RNAi agents preferentially induce apoptosis of HIV infected macrophages. RNAi agents, and macrophages containing the RNAi agents, are also provided.