METHODS FOR INHIBITING HUMAN IMMUNODEFICIENCY VIRUS (HIV) RELEASE FROM INFECTED CELLS

摘要

The finding that human immunodeficiency virus (HIV) envelope glycans bind CD62L (L-selectin) on central memory T cells is described. HIV infection is also shown to induce shedding of CD62L and this shedding is required for efficient release of HIV from infected cells. Methods of inhibiting HIV release from infected cells using inhibitors of CD62L sheddase are described. Methods of treating HIV infection with a CD62L sheddase, such as in combination with antiretroviral therapy, is also described.