首页> 外国专利> Crystalline forms of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide

Crystalline forms of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide

机译:(R)-N-((4-甲氧基-6-甲基-2-氧代-1,2,二氢吡啶-3-基)甲基)-2-甲基-1-(1-(1-(2 ,2,2-三氟乙基)哌啶-4-基)乙基)-1H-吲哚-3-羧酰胺

摘要

The present disclosure relates to a crystalline Forms A, B, and C of (R)—N-((4-methoxy-6-methyl-2-oxo-1,2-di-hydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide, each of which are useful as modulators the activity of histone methyl modifying enzymes. The present disclosure also provides pharmaceutically acceptable compositions comprising the crystalline forms and methods of using said compositions in the treatment of various disorders.; embedded image
机译:本公开涉及(R)— N-((4-甲氧基-6-甲基-2-氧代-2-氧代-1,2-二氢吡啶-3-基)的晶型A,B和C甲基)-2-甲基-1-(1-(1-(1-(2,2,2-三氟乙基)哌啶-4-基)乙基)-1H-吲哚-3-羧酰胺,它们各自可用作调节活性的化合物组蛋白甲基修饰酶本公开还提供了包含结晶形式的药学上可接受的组合物,以及使用所述组合物治疗各种疾病的方法。 “嵌入式图像”

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