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Nucleic acids for single-domain antibodies with thermal stability under cytoplasmic expression
Nucleic acids for single-domain antibodies with thermal stability under cytoplasmic expression
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机译:在细胞质表达下具有热稳定性的单域抗体核酸
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摘要
A nucleic acid encodes a single-domain antibody (sdAb) is produced by causing a bacteria to express the sdAb into cytoplasm of the bacteria, wherein the sdAb is expressed as a fusion protein with the acid tail of α-synuclein. In embodiments, the protein is free of a periplasmic location tag. Such antibodies have the unexpected ability to refold after thermal denaturation.
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