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Artificial nucleases including engineered FokI cleavage half-domains
Artificial nucleases including engineered FokI cleavage half-domains
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机译:人工核酸酶,包括工程化的FokI切割半结构域
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摘要
Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.
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