The invention relates to the field of biomedicine, in particular to providing a selective TNFR1 antagonist peptide derived from the snake venom of Qinghai Hydrostatin-SN10 has the amino acid sequence as shown in SEQ ID NO: 2. The present invention also provides a selective TNFR1 antagonist peptide PEG-SN10 based on mPEG2000 modification, which is selectively modified by covalent attachment of the carboxyl group of mPEG2000 to the free amino group of the N-terminal aspartic acid of Hydrostatin-SN10 peptide chain. At the same time, the present invention provides the use of the selective TNFR1 antagonist peptides Hydrostatin-SN10 and PEG-SN10 for the prevention and treatment of rheumatoid arthritis.
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机译:本发明涉及生物医学领域,特别是提供一种衍生自青海水抑素-SN10蛇毒的选择性TNFR1拮抗剂肽,其氨基酸序列如SEQ ID NO:2所示。本发明还提供了一种选择性TNFR1拮抗剂肽PEG-SN10,基于mPEG2000修饰,可通过将mPEG2000的羧基共价连接到Hydrostatin-SN10肽链N末端天冬氨酸的游离氨基上进行选择性修饰。同时,本发明提供了选择性TNFR1拮抗剂肽水抑素-SN10和PEG-SN10在预防和治疗类风湿性关节炎中的用途。
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