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HIGHLY ACCURATE DE NOVO POLYNUCLEOTIDE SYNTHESIS
HIGHLY ACCURATE DE NOVO POLYNUCLEOTIDE SYNTHESIS
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机译:高度精确的从头合成多核苷酸
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摘要
Methods, systems, compositions, and devices for the manufacturing of high-quality building blocks, such as polynucleotides, are described herein. Processes described herein provide for efficient washing of residual reagents, solvents, or byproducts from previous synthetic steps to allow for the generation of polynucleotides with low error rates. Processes described herein also provide for reduction in deletion rates during chemical nucleic acid synthesis. Further, methods and devices described herein allow for the rapid construction and assembly of large libraries of highly accurate polynucleotides.
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