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Markers of Triple-Negative Breast Cancer and Uses Thereof

机译:三阴性乳腺癌的标志物及其用途

摘要

In one aspect provided herein are methods of determining a triple negative breast cancer (TNBC) subtype in an individual in need thereof comprising determining expression of one or more genes in one or more TNBC cells of the individual; and comparing the expression of the one or more genes in the TNBC cells with the expression of the one or more genes in a control. In another aspect, the methods are directed to determining a treatment protocol for the TNBC patient based on the TNBC subtype. In another aspect, the methods are directed to predicting whether an individual will benefit from a treatment for a particular TNBC subtype. In yet another aspect, the invention is directed to a method of determining whether an agent can be used to treat a TNBC subtype.
机译:在一方面,本文提供了在需要其的个体中确定三阴性乳腺癌(TNBC)亚型的方法,包括确定该个体的一个或多个TNBC细胞中一种或多种基因的表达;并将TNBC细胞中一种或多种基因的表达与对照中一种或多种基因的表达进行比较。在另一方面,该方法针对基于TNBC亚型为TNBC患者确定治疗方案。在另一方面,这些方法旨在预测个体是否将从特定TNBC亚型的治疗中受益。在另一方面,本发明涉及确定试剂是否可用于治疗TNBC亚型的方法。

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