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DNA probe library for hybridization with microsatellite instability related microsatellite loci, detection method and kit
DNA probe library for hybridization with microsatellite instability related microsatellite loci, detection method and kit
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机译:用于与微卫星不稳定性相关的微卫星基因座杂交的DNA探针库,检测方法和试剂盒
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摘要
A DNA probe library for hybridization with microsatellite loci associated with microsatellite instability (MSI) detection. The said DNA probe library comprises one or more DNA probes that are capable of hybridizing with the MSI status-related microsatellite loci. Among the said DNA probes, probes for the MSI-related microsatellite loci are shown in the following sequences: SEQ ID NOS. 1-66. In addition, the present invention provides a method for enriching and detecting the MSI-related microsatellite loci using the probe library. The combination of this method and next-generation sequencing technology (NGS) can greatly improve the sensitivity, accuracy and comprehensiveness of the MSI detection.
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机译:用于与微卫星不稳定性(MSI)检测相关的微卫星基因座杂交的DNA探针库。所述DNA探针库包含一种或多种能够与MSI状态相关的微卫星基因座杂交的DNA探针。在所述DNA探针中,MSI相关的微卫星基因座的探针显示在以下序列中:SEQ ID NOS。 1-66。另外,本发明提供了使用探针库富集和检测MSI相关的微卫星基因座的方法。该方法与下一代测序技术(NGS)的结合可以大大提高MSI检测的灵敏度,准确性和综合性。
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