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BOTULINUM NEUROTOXINS WITH MODIFIED LIGHT CHAIN SPECIFITY AND METHODS FOR PRODUCING SAME
BOTULINUM NEUROTOXINS WITH MODIFIED LIGHT CHAIN SPECIFITY AND METHODS FOR PRODUCING SAME
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机译:具有改良光链特异性的肉毒杆菌神经毒素及其制备方法
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摘要
A protease directed to a non-neuronal SNARE protein is described. The protease is produced by selective mutation of a botulinum neurotoxin light chain, and is characterized utilizing a reporting construct that includes all or part of the non-neuronal SNARE protein. Such a protease has utility in the treatment of diseases associated with hypersecretion, where the hypersecretion is mediated by a non-neuronal SNARE protein.
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