COMPOSITION COMPRISING AZELAIC ACID OR AS ACTIVE INGREDIENTS FOR MUSCLE STRENGTHENING, DEVELOPMENT, DIFFERENTIATION, REGENERATION OR INHIBITING MUSCLE ATROPHY

摘要

The present disclosure relates to a pharmaceutical composition for preventing or treating a muscle disease, comprising, as an active ingredient, azelaic acid or a pharmaceutically acceptable salt thereof. In muscle cells, the azelaic acid according to the present disclosure can increase expression of proteins associated with muscle protein synthesis and muscle mass increase and can inhibit expression of enzymes involved in muscle protein degradation; and therefore the azelaic acid can exhibit a muscle strength-enhancing effect through muscle differentiation, muscle regeneration, and muscle mass increase in a muscle disease caused by muscle function decline, muscle wasting, or muscle degeneration. In addition, the azelaic acid can inhibit muscle decrease. Accordingly, the azelaic acid can be used for preventing or treating a muscle disease, differentiating muscles, regenerating muscles and enhancing muscles, or for increasing muscle mass, promoting muscle production, or improving muscle function.